The SPACEHAB Payload Processing Facility (SPPF) hosts all payload integration activities for the SPACEHAB module and ICC fleets. Located on a commercial site just south of Cape Canaveral, the SPPF is designated as a Foreign Trade Zone and is completely independent of Kennedy Space Center (KSC) operations. This 58,000 square foot facility offers Class 100,000 clean room accommodations, providing mechanical and electrical ground support equipment enabling the carriers and their payload complements to be tested prior to delivery to the nearby KSC for final integration into the shuttle.

Payload customer teams are housed in one of eleven industrially-secure customer work areas. Much like the facilities they occupy, the SPACEHAB staff tasked with conducting ground operations is equipped with the latest technologies as well as an ever-expanding knowledge base to fulfill customer objectives in support of SPACEHAB's growing complement of flight assets and services. Some of the amenities provided in this facility include bonded storage, 14,000 sq ft integration hall, and administrative support areas.